pentobarbital will lessen the extent or effect of fostemsavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.pentobarbital will minimize the extent or impact of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Lack of, or diminished reaction to tofacitinib may perhaps happen when